4/6/2023 0 Comments Baytril side effect![]() This is one of many reports highlighting the increase of fluoroquinolone resistance in zoonotic bacteria.įluoroquinolones act by directly inhibiting DNA gyrase and topoisomerase IV in susceptible bacteria. Of those, 40% had a reduced susceptibility to the fluoroquinolone enrofloxacin. Received 28 March 2003 returned 24 July 2003 revised 11 August 2003 accepted 29 October 2003 IntroductionĪ national survey has reported that almost one in 10 Salmonella enterica serotype Typhimurium DT104 strains isolated from porcine origin were resistant to nalidixic acid (National Abattoir Survey, Veterinary Laboratories Agency, UK, 2000). Keywords: zoonotics, antimicrobial resistance, animal models ![]() Typhimurium DT104 outlasted the current withdrawal time of 10 days for Baytril (commercial veterinary formulation of enrofloxacin).Ĭonclusions: In conclusion, our study has provided direct evidence that enrofloxacin-treated pigs could be entering abattoirs with higher numbers of quinolone-resistant zoonotic bacteria than untreated pigs, increasing the risk of these entering the food chain. However, the effect of enrofloxacin on the nalidixic acid-resistant and cyclohexane-resistant S. Emergence of fluoroquinolone resistance was not detected during treatment or post-treatment in any of the Salmonella strains monitored. ![]() Typhimurium DT104 strains that are already nalidixic acid resistant ( gyrA Asn-87) or cyclohexane resistant, the latter being indicative of an up-regulated efflux pump. We also provide evidence that treatment positively selects for S. Typhimurium DT104, which continued to be isolated up to 35 days after treatment. Results: Our results showed that a single treatment failed to eradicate S. The objective of our study was to investigate the effect of a single 5 day enrofloxacin treatment on Salmonella enterica serotype Typhimurium DT104 in a pig model. Objectives: There are concerns that the use of enrofloxacin in livestock production may contribute to the development of fluoroquinolone resistance in zoonotic bacteria.
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